does semaglutide make you feel depressed and Depression: What Is the Relationship? Semaglutide vs. Tirzepatide: Mental Health

World Journal of Gastroenterology: WJG, 20 (5), 1165-1179

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Understanding these potential pathways helps clinicians and patients identify the underlying cause and implement appropriate management strategies

Elevated cAMP activates PKA and phosphorylates cAMP-response element binding protein (CREB), inhibiting p65/RelA and p50 activation as well as their DNA binding ability by delaying IKB- degradation and competing for the KIX binding site on CREB binding protein (90)

Semaglutide supports this by providing cellular protection and reducing stress