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TB-500 itself remains an investigational compound, meaning it has not been approved as a standalone drug by the FDA

When looking at patterns of parasympathetic innervation in human pancreatic islets it was noted that human islets not only demonstrate weak parasympathetic innervation but that alpha cells were positive for the classical marker of parasympathetic neurons, namely, the vesicular acetylcholine transporter (vAChT) [23]

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Materials and Methods Animals Wistar male rats of approximately 3 months age, weighing 150 20 g, were acquired from the house of animals at Faculty of Pharmacy, Cairo University, Cairo, Egypt