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The fraction of intact sermorelin that reaches systemic circulation through this route is not consistent across patients, is not validated in controlled clinical trials for adult GH optimization, and is not comparable to what subcutaneous injection achieves in terms of IGF-1 response

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HUBERMAN: And injured capillaries, and then to promote the activity of a given enzyme called ENOS or endothelial nitric oxide synthase, which then causes more blood vasculature to form at the injury site and around the injury site