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Effects Beyond Weight Loss One of the most important insights from this research is: Weight loss alone does not explain the benefits In the case series: Some patients had symptom improvement without weight loss Tissue thickness decreased even when weight stayed the same This supports the idea that GLP-1s may be acting directly on: Inflammation Blood flow Adipose tissue biology Are GLP-1 Medications a Treatment for Lipedema

NF-B is a crucial transcription factor that activates many proinflammatory genes

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