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"During pregnancy, the demand for nutrients like vitamin B12 increases

The hypothesis provides tenable predictions that may be tested in rigorously designed experiments in vitro and in vivo

Increases in calcitonin levels have been observed in some patients, though the clinical significance remains uncertain

[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, headaches, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, hair and skin color changes, numbness or tingling (pins and needles) of the fingers and toes, and tinnitus, and vision, cognitive or psychological problems

In their review, Doets et al