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The only meaningful comparison context is against the other agents in the class, covered in our Retatrutide vs Semaglutide vs Tirzepatide analysis, and the two entry points for the protocol itself are the 5 mg vial protocol for a gentle start and the 30 mg vial protocol for higher maintenance targets

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For patients taking warfarin, more frequent INR monitoring is recommended during semaglutide initiation or dose changes, as a prudent clinical practice

Levothyroxine : Co-administration with semaglutide increases thyroxine exposure