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Wall Street called the selloff overdone. BMO Capital Markets analysts noted that with insured individuals in the US already paying as low as $25/month for GLP-1 medications, we continue to view any ultimate negotiated MFN price as more of a headline risk versus a true fundamental change to the companies businesses

Prevalence of gestational diabetes mellitus (GDM)

Patients transitioning from liraglutide to tirzepatide are therefore moving to a drug that has demonstrated roughly 2.5 times greater mean weight loss in separate trials

While IcoSema and basal-bolus insulin showed similar results for time in range, IcoSema had a lower percentage of participants below range (glucose below 54 mg/dL)

The major obstacle in developing such therapies will be the ubiquitous presence of the UPS in eukaryotes which may require nanomedicine approaches or other tissue-targeting strategies to minimize adverse effects of such therapies