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Heightened Fatigue: Some individuals experience GLP-1 fatigue as the medication reaches its peak

Again, a Phase 2 trial, recruiting patients with type 2 diabetes, randomised 281 adults to retatrutide, to a comparison drug that is already used in diabetes clinics (dulaglutide, a once-weekly drug that activates only one of retatrutide's three target receptors), or to a dummy injection (placebo) over 36 weeks

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That advantage owes nothing to the studys finding on survival but the two happen, for now, to point in the same direction