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Mild itching may occur, and hair in affected areas can turn white

Hypoxia stabilizes HIF-1 and HIF-2, driving maladaptive angiogenesis and VEGF-dependent profibrotic signaling that results in fragile, poorly functional capillaries [31,32]

A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45

Consequently, these studies provide continued support that maintaining optimal cellular levels of glutathione is important for effective cellular function

Chemical induced or contact/occupational vitiligo is a depigmenting disorder of the skin caused by exposure to chemical and physical agents present at the workplace or in the environment (Alam and Ghosh 2017