In people with major depressive disorder and a chronic physical condition, mitochondrial ATP production decreases in muscle cells.[ref] Another post-mortem study on the brains of patients with depression, bipolar, or schizophrenia showed a specific mitochondrial protein (NDUFS7) involved in ATP production decreased significantly in patients with bipolar disorder.[ref] Ketogenic diet: A ketogenic diet is very low in carbohydrates, which causes a shift in the way that mitochondria produce energy
10.1016/j.jss.2011.06.033 [DOI] [PubMed] [Google Scholar] 174.Yang K, Liu X, Liu Y, Wang X, Cao L, Zhang X, et al
You may not be able to reach this area easily by yourself, so if you want to do the injection here, you should ask someone to administer the shot for you
A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)
The objective of their research was to investigate the associations between uric acid concentrations and various health conditions, including body mass index, bone mineral density, coronary artery disease, blood pressure, metabolic syndrome, blood glucose levels, triglyceride levels, diabetes mellitus, serum creatinine levels, estimated glomerular filtration rate, Parkinsons disease, memory, and gout
