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While no official report has quantified the reach and impact of the shortage, research into Hims & Hers customers found that nearly 30% of Weight Loss customers who had been prescribed a branded GLP-1 in the past were unable to fill it because the medication was not available at their pharmacy

However, the additive effects of the combination therapy can lead to an increase in the risk of dehydration leading to a decreased glomerular filtration rate

Our recent study addressing this treatment concept showed modest weight-loss effects [30, 31], but further studies with optimized doses are encouraged

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EXSCEL alone reported 22% of patients had reduced LVEF