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Microdosing is used off-label to reduce the incidence of these side effects and improve the bodys tolerance

The TRIUMPH-4 Phase 3 data provides the most current safety information: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) versus 0% placebo Decreased appetite: 19.0% (9 mg) to 18.2% (12 mg) versus 9.4% placebo The pattern is clear

To lower the risk of developing sudden side effects, your provider may increase the dose over time until you reach a maintenance dose between 5 mg-15 mg

Monitor the injection site Its normal for there to be a drop of blood on your skin right after your injection

Following this dose management approach ensures patients wont disrupt their treatment schedule and maintains the effectiveness of the medication