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In conclusion, our findings suggest that overexpression of lamin A/C may not have a directly effect on the examined mutant phenotypes, such as impaired swim speed, increased heart rates, or decreased muscle fiber diameter

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Acta Biomed, 79 , 205-210

This sustained occupancy is what drives the consistent A1C and weight reductions seen in long-duration SURPASS trials rather than a pulse-and-wane effect

Reaching higher doses often correlates with greater weight loss