why is everyone taking glp 1 GLP-1s have been dominating the headlines recently. For me, the change these medicines are having on nutrition, public health and how we treat metabolic medicine something I've spent years teaching, researching Why I'm Choosing Not to

Based on Obesity Canada guidelines and clinical trials (typically over ~1 year): Saxenda: ~58% total body weight loss Wegovy: ~1015% total body weight loss Tirzepatide: ~1520% (or more) total body weight loss weight loss is gradual and occurs over several months, with the most significant changes seen after reaching the full therapeutic dose results vary depending on adherence, lifestyle factors, and individual response 7

Benign thyroid nodules are not a contraindication to tirzepatide use

The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively

While Samols was away another group of researchers at the Royal Free Hospital made a significant breakthrough in unravelling the role of the pancreas islet cells in insulin secretion

Evidence-based calculator to preserve muscle during weight loss