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Most GH secretion occurs during slow-wave sleep, so getting seven to nine hours of quality sleep per night helps your body naturally repair and build muscle

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

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Mattson et al., 2008

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