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10.1093/cercor/bhy194 Cereb

One third of dementia cases can be prevented within the next 25 years by tackling risk factors

Rare but serious side effects require awareness

"Obesity, like many other chronic diseases, is a progressive, relapsing disease, which may require long-term treatment," Jaisinghani says a framing now codified in the World Health Organization's first global GLP-1 guideline, issued in December 2025, which conditionally recommends these therapies as part of a comprehensive obesity treatment approach

Lubricant Laxatives Examples: Mineral oil Mechanism: Coats stool prevents water absorption softens stool Uses: Chronic constipation, fecal impaction Adverse Effects: Aspiration lipid pneumonia