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163,164,198,199 Breakdown of ion homoeostasis ion gradients, uncontrolled neurotransmitter release, oedema and mitochondrial failure are thus the key mechanisms behind pathophysiology of the ischaemic stroke

Sufficient G6PD activity appears to be crucial for inflammatory macrophage function as well

In spinal cord injury, this peroxidation has been shown to precede mitochondrial dysfunction [83], while inhibition of lipid peroxidation with 21-aminosteroid in rats attenuated controlled cortical impact (CCI)-induced decreases in mitochondrial respiration [84]

138 With this in mind, novel gene delivery systems for gene therapy can be made with several nanomaterials, including carbon nanotubes (CNTs), 139 nano-graphene oxide, 140 nanoscale polymeric materials, as well as peptide and protein-based nanoparticles

Front Pharmacol 5:196