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Ideal candidates include adults with: BMI 30 (obesity) BMI 27 with weight-related conditions (type 2 diabetes, hypertension, high cholesterol, sleep apnea, PCOS) Inability to lose weight through diet and exercise alone Contraindications include: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN 2) History of pancreatitis (caution advised) Your online doctor will evaluate all risks and benefits before prescribing

Originally approved for diabetes management, glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide have rapidly crossed over into mainstream aesthetic practice by delivering dramatic weight loss in remarkably short time frames

Try these extra comfort strategies: Room Temperature Medication: If your pen is too cold, let it sit at room temperature for 10-15 minutes before injecting

Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus

Life Sci (2013) 92(10):53340.10.1016/j.lfs.2013.01.001 26 MabilleauGMieczkowskaAIrwinNFlattPRChappardD