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59 The clinical benefit offered by these devices is controversial, 6062 thus limiting their use to experimental purposes only

Molecular investigations were performed for TRPV1, NR2B, neuro-inflammatory and glia cell markers (TNF-, IL-6, Iba-1 & ICAM-1), and neuropeptides (CGRP), using western blotting and RT-PCR analysis

Lee and Jun 2016)

Conversely, the review also explores the potential of NAC as an antioxidant and a GSH-boosting agent, highlighting its capacity to cross the bloodbrain barrier and influence critical cysteine-containing proteins within the brain