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525 Sodium channel inhibitors Carbamazepine and oxcarbazepine: Recently included as first-line treatments in guidelines, carbamazepine and oxcarbazepine reduce neuronal excitability by blocking voltage-gated sodium channels

Serious adverse effects are uncommon in healthy adults but can include elevated homocysteine levels if methionine metabolism is impaired, which is why patients with MTHFR gene variants should use methylated B-vitamin formulations instead of standard Lipo C

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