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Some anti-diabetic medications are linked with an increased risk of weight gain or hypoglycemia which may reduce the efficacy of the intended anti-hyperglycemic effects of these therapies

To address these challenges, several strategies have been explored to minimize the adverse effects of melittin while retaining its therapeutic potential

Kailey B, van de Bunt M, Cheley S et al (2012) SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells

These enzymes are strongly FAD-dependent, and mutations often destabilize FAD-binding motifs or enzyme complexes, impairing fatty acid -oxidation and energy homeostasis