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In recent years, dual agonists of the incretin system have been tested in pre-clinical and early-phase clinical trials, with the glucose-dependent insulinotropic polypeptide and GLP-1 co-agonist, tirzepatide, recently approved for clinical use

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8 Moreover, one should consider the fact that different GLP-1 RAs were used across the studies, with different chemical structures, durations of action and weight-lowering effects, which may impact their efficacy

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