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One more twist that you might not expect: We have observed that some super responders are not quite sure how to live in their body after losing, say, 100 pounds

If weight loss is your primary goal, especially for medically significant amounts, the evidence strongly favors prescription GLP-1 therapy

Insulin exerts its biological effect through interaction with the insulin receptor [127]

However, following discontinuation of medication, patients clinical markers either returned to baseline levels or worsenedsuggesting that patients need to remain on to maintain benefits

In addition, the absence of key study design features, such as control groups or randomization, limits the ability to draw firm conclusions about cause and effect