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Upon phosphorylation by RIPK3, MLKL undergoes oligomerization and translocates to the plasma membrane, where it induces pore formation

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( D F ) Glucose tolerance test (GTT) following intraperitoneal glucose injection in male PAR2-G37I and WT ( n = 15/15) and PAR2-R38E and WT ( n = 7/8) ( D ) or female PAR2-G37I, PAR2-R38E, and WT ( n = 7/7/6) ( E ) and quantification of area under the curve for both male and female PAR2-G37I and PAR2-R38E versus WT mice ( F )