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Half-life values are derived from specific assay conditions typically IV bolus administration in a single species with healthy plasma and may not reflect the pharmacokinetics observed under different experimental circumstances
To overcome the drawbacks, researchers are attempting to deliver drugs to the site of action (targeted delivery) or to identify drugs that specifically target tumor cells
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conducted prospective and retrospective observational studies on the efficacy of the combination of duloxetine (DLX) and pregabalin (PGB) for the treatment of FM syndrome, and the possibility of additional benefits with the addition of the lipid signaling molecule palmitoylethanolamide (PEA) [59]
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