Among 69,221 propensity-matched patients with IBD, those who had received a GLP-1 RA had a 5-year colorectal cancer incidence of 0.2% compared with 0.42% in non-GLP-1 RA users (OR, 0.49), corresponding to a 51% reduction in odds of developing colorectal cancer
employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor (ROR) (ROR-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via ROR-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28]
the SURMOUNT-1 trial reported up to 22% with tirzepatide over 72 weeks
Ozempic and meals Semaglutide medication, such as Ozempic, doesnt need to be taken at specific meal times, Dr
Consistent with this, we show the G protein can allosterically influence GLP-1R agonist affinity, but this occurs in a peptide-dependent manner