The move is part of the agencys decisive steps to safeguard consumers from illegal GLP-1 active ingredients imported from overseas and to ensure a secure drug supply chain
The net effect is a half-life of approximately 2030 hours compared to the 1215 minutes of free native IGF-1, and a substantially elevated free peptide fraction that is available for receptor engagement
Independent Program Data# Liraglutide (SCALE program) : The SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015) enrolled 3,731 adults without diabetes
Xue YZ, Wang LX, Liu HZ, Qi XW, Wang XH, Ren HZ (2007) L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction
Summary: Wegovy can generally be used safely in people with well-controlled hypothyroidism on stable levothyroxine therapy, with no specific contraindication listed in UK prescribing guidance