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For current market leaders, sustained dominance will hinge on an ability to navigate an increasingly uncertain regulatory and pricing environment and manage quality and safety concerns amid heightened scrutiny of GLP-1 drugs long-term effects and off-label use

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The safety of liraglutide (and exenatide) can only truly be assessed with robust phase IV postmarketing data involving long-term treatment with this novel therapy

But it can also be prescribed off-label for weight reduction because substantial evidence supports its effectiveness