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The metabolic alterations in OC tissue included elevated glycolysis (lactic acid) and TCA cycle intermediates (malic acid, fumaric acid) were related to energy metabolism

TSS pathway activity is suppressed by excess hemin under hypoxia, and the suppression is reversible through DMF treatment The afore findings suggest that supplementing cystine at physiological concentrations is a prerequisite for investigating the function of CBS in SCD erythroblasts

Mithieux 2009

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