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A recently FDA-approved higher dose of Wegovy (Wegovy HD) is 7.2 mg, and may result in even more weight loss compared to the 2.4 mg dose

Some doctors are trying to reduce the negative effects of this by titrating off the medications (giving a lower dose for a period of time to help ease the transition), but ultimately it boils down to this

Weight cycling, weight gain, and risk of hypertension in women

Additionally, rapid dose escalation increases side effect severity, which is why gradual titration over weeksrather than jumping to therapeutic dosesproduces better long-term tolerability and adherence

Meanwhile, the emergence of orally active small-molecule GLP-1 receptor agonists like danuglipron and orforglipron, which are resistant to enzymatic degradation, marks a major advance in patient-friendly drug delivery