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Switching or augmentation strategies, such as with aripiprazole, bupropion, or selective noradrenergic reuptake inhibitors, lithium or nortriptyline produce moderate mood improvement, while multimodal antidepressants, including vortioxetine or duloxetine show cognitive benefit [41, 44, 45] The available studies of adjunctive medication and neurostimulation, such as methylphenidate, nicotine, or transcranial direct-current stimulation (tDCS), demonstrate potential for improving both mood and cognition, in contrast to the cholinesterase inhibitor, donepezil, that was associated with increased depression relapse [46,47,48,49]

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References Benoist CC, Kawas LH, Zhu M, et al

Warnings: Consult a healthcare professional before using this product if you are trying to conceive, pregnant, or lactating, under the age of 18, or have a medical condition