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Metformin treatment throughout pregnancy in women with PCOS does not cause significant adverse effects such as fetal growth retardation or intrauterine death ( 3.3.2 Effect of metformin on offspring malformations in patients with polycystic ovary syndrome The period of early pregnancy is critical for organogenesis and the potential teratogenic effects of drugs

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In the absence of safety data, most clinicians advise that pregnant or breastfeeding individuals avoid this compounded preparation unless the anticipated benefit clearly outweighs theoretical fetal or neonatal risks