Early preclinical and small-scale human studies suggest these drugs may influence brain reward pathways involved in addictive behaviours, potentially reducing alcohol cravings and intake
A person burning 2,800 calories daily who drops to eating 1,500 calories faces a 1,300-calorie deficit, compared to a sedentary person burning 2,000 calories with the same food intake facing only a 500-calorie deficit
Both can be supplemented safely alongside GLP-1 medications, but should be taken at least 4 hours away from levothyroxine to avoid absorption interference
These findings are further supported by another sub-analysis of SURMOUNT1, which reported a 33.9% (8.2% for placebo) reduction in fat mass and a 10.9% (2.6% for placebo) reduction in lean mass by week 72, with approximately 75% of weight loss attributable to fat mass, consistent across clinically relevant subgroups [68]
(see my Instagram post) Its about nourishment