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Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

P53 directly increases GH production, endocrine GH promotes the expression of ATM through JAK2-activated TRIM29, and next regulates HR pathway to repair DNA damage (Sho et al., 2011)

Each approach has different evidence levels, timelines, and side effect profiles understanding the mechanisms helps in evaluating which compounds have the strongest research support for specific fat loss goals