does tirzepatide affect liver A Rare Case of Tirzepatide-Induced Hepatitis: Causality Assessment With the RUCAM Criteria What Is Fatty Liver Disease?

MOTS-c is a 16-amino acid mitochondrial-derived peptide evaluated for exercise-associated signaling mimicry in laboratory settings

Key preclinical findings included: Dose-dependent weight loss exceeding that of single- or dual-receptor agonists Improved glucose tolerance and insulin sensitivity Increased energy expenditure attributable to the glucagon receptor component Reduced hepatic steatosis Acceptable preclinical safety and toxicology profile These data supported an Investigational New Drug (IND) application to the FDA, enabling the transition to human clinical testing

Ladas SD, Malamou-Lada H, Economou G, Tassios PS, Raptis SA

Although L-cells are classically described as endocrine cells, like enterochromaffin cells (Bellono et al., 2017), they can synapse directly with peripheral afferent and efferent neurons (Bohrquez et al., 2015), providing a direct neural pathway for bi-directional brain-gut communication (Kaelberer et al., 2018)

Addict Subst Abuse 2020;1:3-8