At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / green tea extract (GTE), standardized to EGCG (epigallocatechin gallate) Primary concern / additive hepatotoxicity at GTE doses 400 mg EGCG/day Secondary concern / CYP1A2 and CYP3A4 modulation may shift isotretinoin metabolism Dietary green tea risk / low, typical brewed cup contains 50 to 100 mg EGCG Monitoring required / LFTs (ALT, AST) at baseline and weeks 4, 8 per iPLEDGE protocol FDA DILI signal / GTE linked to drug-induced liver injury in 29 case reports reviewed by NIH LiverTox Recommendation / avoid concentrated GTE supplements during isotretinoin
Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4
After washing with PB, sections were incubated in donkey anti-goat Alexa-Fluor 594 (1:500, Thermofisher) in PB for 1.5 hours at room temperature
Post-acute COVID-19 was related to hyperactivated innate immune cells and T and B cells, along with elevated expression of the proinflammatory cytokine, such as IFN- and IFN-1 that remained persistently high at 8 months after infection (Phetsouphanh et al., 2022)
What Are Branch Chain Amino Acids (BCAAs)
