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Lancet 375:14471456 Mannucci E, Ognibene A, Cremasco F et al (2001) Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects

Gastroenterology (2015) 149:2535

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In order to capture this complexity, we have, in collaboration with clinicians and experimentalists, developed mathematical models based on the real underlying physiology [10-16]

A study of humans with a genetic mutation for CYP2R1, or those done using CYP2R1 knockdown mouse models, demonstrate low circulating levels of 25(OH)VD 3 24