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Rotate injection sites to prevent lipodystrophy 9 Store reconstituted solution refrigerated (28C) and use within 28 days Week 12 Initial effects and adaptation period

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Compared to the inactive GCGR, the extracellular tip of TM7 in peptide 20-bound GCGR moved outward by 5.1 (measured by C atom of L377 7.34b ) and the -helical structure of the extracellular half of TM6 was partially unwounded