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In controlled clinical trials, daily intakes of aged garlic extract at doses between 1.2 g-2.4 g (containing 1.2 to 2.4 mg of S-allyl-L-cysteine) consistently resulted in reductions in SBP by 9 mm Hg-10 mm Hg and reductions in DBP by 4 mm Hg-8 mm Hg in a majority of patients with uncontrolled hypertension (110, 143)

Regarding the priority of testable mechanisms at this stage, the SCFAsmodule (specifically butyrate) commands a relatively higher verification priority due to the existence of closed-loop clues involving ABX depletion effect + FMT transferability + Metabolite rescue. Conversely, bile acids/tryptophan and multi-metabolic pathway reprogramming are better suited as a pool of candidate mechanisms, still requiring convergence to the level of key molecules and receptors/pathways through Supplementation/Blocking shortest closed-loop experiments

S Afr J Bot 142:106113

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