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NEJM Evid
Given that brain inflammation is an immune response mediated by microglia and astrocytes, it has been postulated that the anti-neuroinflammatory effect of GLP-1RAs could be in part due to their inhibitory action on astrocytes and microglia via the activation of cAMP/PKA signaling [82]
Unlike morning dosing, which gets built into the start-of-day routine, evening dosing competes with relaxation, family time, and simple exhaustion
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