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Pediatric HF exhibits similar changes, indicating that these alterations are not limited to adult or ischemic disease ( 3.2 Mitochondrial DNA mutations Mitochondrial DNA (mtDNA) is particularly vulnerable to injury in the failing heart ( Multiple studies have identified mtDNA deletions and point mutations in the myocardium of HF patients

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J Physiol Pharmacol 66:191202 [PubMed] [Google Scholar] Salim S (2017) Oxidative stress and the central nervous system