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Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis
But side effects are very under-reported. About half of adults who start GLP-1s stop within a year some because their insurance coverage changes with many reporting gastrointestinal side effects as a contributor
Veljaca, Marija et al, The development of PL 14736 for treatment of inflammatory bowel disease, Advanced in GI pharmacology, 2002 O-32
Signs of liver problems while taking semaglutide may include jaundice (yellowing of the skin and eyes), dark urine, fatigue, nausea, vomiting, abdominal pain, and unexplained itching
