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This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (Table 1 gives a summary of the clinical phase III studies with at least 52 weeks duration on the efficacy of DPP-4 inhibitors compared to sulfonylureas as add on therapy to metformin, respectively, in patients not reaching their glycaemic goals with a monotherapy of metformin

The highest comorbidity (Presence of two or more health conditions at once in the same person) associated with obesity is T2DM

cDNA was synthesized using the PrimeScript 1st strand cDNA Synthesis Kit (Takara Bio, Shiga, Japan)

Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus