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Chronic inflammation can disrupt the synthesis, release, and reuptake of key neurotransmitters, including serotonin, dopamine, and norepinephrine

We have two studies showing anatomical regression of atherosclerosis and a recent study from our group showing [pioglitazone] improves diastolic dysfunction, suggesting that it may actually have some benefit in heart failure with preserved ejection fraction, DeFronzo said

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By week 48 the 12 mg arm averaged 24.2 percent loss, the 8 mg arm landed near 22.8 percent, and even the 4 mg arm reached about 17.1 percent