surmount-1 tirzepatide weight loss percent 72 weeks Adults with obesity using maintain 'remarkable' at 88 SURMOUNT‐1 study design. This is

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The authors found that existing research had shown that individuals using exenatide (brand name Byetta) another GLP-1 analogue had decreased neuronal responses to pictures of food in parts of the brain regulating appetite and reward

Sustainable weight loss and lasting change depend on meaningful lifestyle choices, including healthier nutrition and more physical activity

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Side Effects and Safety Profile Common Side Effects Gastrointestinal effects are the most frequently reported adverse events in clinical trials: Nausea (reported by 1233% of participants depending on dose) Diarrhea (1223%) Constipation (611%) Vomiting (59%) Decreased appetite (considered both a therapeutic effect and side effect) Abdominal pain (58%) Dyspepsia/heartburn (58%) These effects are most common during dose escalation and typically improve within 24 weeks at each new dose level