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Baird L, Lleres D, Swift S, Dinkova-Kostova AT

cruzi infection, which modulates systemic infection levels and inflammatory responses in cardiac tissue and reduces immune cell infiltration, cardiomyocyte hypertrophy, fibrosis and the parasite load in heart tissue ( 2 +/NFAT-dependent pathological COX-2/mPGES-1/PGE2 pathway in trypanosome-infected cardiomyocytes, potentially conferring cardioprotection in infected mice ( In conclusion, the role played by COX-2 in Chagas disease may be related to the attenuation of increased NO levels, negatively affecting the antiparasitic activity of macrophages

They performed a forward Mendelian randomization analysis using Levo-carnitine and its derivatives as exposures and schizophrenia as the outcome, sourcing candidate data from the Open-GWAS database

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