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Cagrilintide starts amylin receptors, very in the area postrema of the brainstem (a key satiety center) and the stomach

J Biol Chem 279:1624616253

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At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]