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Clinical translation of cardiovascular applications lags substantially behind analogs for other conditions, such as metabolic diseases, blood disorders, and cancer

doi: 10.1016/j.bbr.2016.10.010 108 SartaT

Through the SH2 domain in the receptor, IGF-IR binds to the SH2 domain of Grb2, which, in turn, complexes with Sos, a guanine nucleotide exchange factor that mediates GDP/GTP exchange in Ras GTPase, and leads to Ras activation