Retinol often triggers a "retinization" period marked by dryness and peeling due to temporary retinol skin barrier disruption
Serotypes such as AAV1, AAV6, AAV8, and especially AAV9 have demonstrated efficient cardiac transduction in small and large animals, enabling robust gene transfer to myocardium with intracoronary or intravenous delivery (Mazurek et al., 2024)
Yang Tang, [email protected] These authors have contributed equally to this work and shared first authorship This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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While both interventions derive from the growth hormone molecule, their safety profiles differ substantially due to AOD-9604s selective mechanism that avoids traditional GH receptor activation