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However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

Mechanistic studies such as the U.S

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The unit conversions are as follows: Natural vitamin E ( --tocopherol) containing supplements: RRR IU of RRR --tocopherol x 0.67 = mg of RRR --tocopherol Example: 100 IU of natural vitamin E provides 67 mg of RRR --tocopherol Synthetic vitamin E ( all - rac --tocopherol) containing supplements: IU of all - rac --tocopherol x 0.45 = mg of RRR --tocopherol Example: 100 IU of synthetic vitamin E provides 45 mg of RRR --tocopherol -Tocopheryl esters -Tocopheryl succinate and -tocopheryl acetate are the main esterified forms of vitamin E in nutritional supplements